4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE

4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE - Names and Identifiers

Name	4,4-Difluoro-L-prolinamide hydrochloride
Synonyms	4,4-Difluoro-l-prolinaMide, HCl 4,4-Difluoro-L-prolinamide hydrochloride 4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE (2S)-4,4-difluoropyrrolidine-2-carboxamide (S)-4,4-difluoropyrrolidine-2-carboxamide HCl (2S)-4,4-difluoro-2-pyrrolidinecarboxamide, HCl -4,4-Difluoropyrrolidine-2-carboxamide hydrochloride (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (2S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride
CAS	426844-51-1
InChI	InChI=1/C5H8F2N2O.ClH/c6-5(7)1-3(4(8)10)9-2-5;/h3,9H,1-2H2,(H2,8,10);1H/t3-;/m0./s1

4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE - Physico-chemical Properties

Molecular Formula	C5H9ClF2N2O
Molar Mass	186.59
Melting Point	222°C
Boling Point	327.5°C at 760 mmHg
Flash Point	151.9°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.000145mmHg at 25°C
Appearance	Solid
Color	Pale Grey to Light Grey
Storage Condition	Inert atmosphere,Room Temperature
MDL	MFCD06797014

4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

4,4-DIFLUORO-L-PROLINAMIDE HYDROCHLORIDE - Introduction

4,4-Difluoro-L-prolinamide hydrochloride is an organic compound with the chemical formula C5H7F2NO · HCl. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White crystalline powder
-melting point: 164-168 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and ether
-Stability: In case of deliquescence, avoid exposure to moisture or water

Use:
-chemical synthesis: can be used as chiral synthesis intermediates, involved in the synthesis of drugs.
-Biochemistry research: can be used for biological activity research, drug screening and protein structure research.

Preparation Method:
4,4-Difluoro-L-prolinamide hydrochloride can be synthesized by the following steps:
1.3,3,4,4-tetrafluoropyridine reacts with carboxymethyl-N-malonamide to generate 3,3, 4,4-tetrafluoro-L-proline imide.
2.3,3, 4,4-tetrafluoro-L-proline imide was reacted with hydrochloric acid to give 4,4-Difluoro-L-prolinamide hydrochloride.

Safety Information:
- 4,4-Difluoro-L-prolinamide hydrochloride is an organic compound, so you need to pay attention to protective measures to avoid contact with skin, eyes and internal inhalation.
-During use, it is recommended to wear personal protective equipment such as protective gloves, goggles and protective clothing to ensure a well-ventilated laboratory environment.
-In case of accidental exposure or inhalation of the compound, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 19:05:49